| | 2022-09-09 03:20 - Round 1 | | | | |
| 2022-09-09 03:20 - Round 1 | Los Angeles Rams | | - | | Buffalo Bills |
| | 2022-09-11 20:00 - Round 1 | | | | |
| 2022-09-11 20:00 - Round 1 | Atlanta Falcons | | - | | New Orleans Saints |
| | 2022-09-11 20:00 - Round 1 | | | | |
| 2022-09-11 20:00 - Round 1 | Carolina Panthers | | - | | Cleveland Browns |
| | 2022-09-11 20:00 - Round 1 | | | | |
| 2022-09-11 20:00 - Round 1 | Chicago Bears | | - | | San Francisco 49ers |
| | 2022-09-11 20:00 - Round 1 | | | | |
| 2022-09-11 20:00 - Round 1 | Cincinnati Bengals | | - | | Pittsburgh Steelers |
| | 2022-09-11 20:00 - Round 1 | | | | |
| 2022-09-11 20:00 - Round 1 | Detroit Lions | | - | | Philadelphia Eagles |
| | 2022-09-11 20:00 - Round 1 | | | | |
| 2022-09-11 20:00 - Round 1 | Houston Texans | | - | | Indianapolis Colts |
| | 2022-09-11 20:00 - Round 1 | | | | |
| 2022-09-11 20:00 - Round 1 | Miami Dolphins | | - | | New England Patriots |
| | 2022-09-11 20:00 - Round 1 | | | | |
| 2022-09-11 20:00 - Round 1 | New York Jets | | - | | Baltimore Ravens |
| | 2022-09-11 20:00 - Round 1 | | | | |
| 2022-09-11 20:00 - Round 1 | Washington Commanders | | - | | Jacksonville Jaguars |
| | 2022-09-11 23:25 - Round 1 | | | | |
| 2022-09-11 23:25 - Round 1 | Arizona Cardinals | | - | | Kansas City Chiefs |
| | 2022-09-11 23:25 - Round 1 | | | | |
| 2022-09-11 23:25 - Round 1 | Los Angeles Chargers | | - | | Las Vegas Raiders |
| | 2022-09-11 23:25 - Round 1 | | | | |
| 2022-09-11 23:25 - Round 1 | Minnesota Vikings | | - | | Green Bay Packers |
| | 2022-09-11 23:25 - Round 1 | | | | |
| 2022-09-11 23:25 - Round 1 | Tennessee Titans | | - | | New York Giants |
| | 2022-09-12 03:20 - Round 1 | | | | |
| 2022-09-12 03:20 - Round 1 | Dallas Cowboys | | - | | Tampa Bay Buccaneers |
| | 2022-09-13 03:20 - Round 1 | | | | |
| 2022-09-13 03:20 - Round 1 | Seattle Seahawks | | - | | Denver Broncos |